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This anomaly is indicative of the larger challenge of culturing various microbial species, referred to as microbial “unculturability.” This cannot be explained by the use of agar alone or by the substitution of an alternative gelling agent, but rather by the difficulties in consistently recreating on an agar plate the multi-variable environment in which microbes grow naturally. Given such challenges, the risk of shortages, and the vulnerabilities of the agar supply chain, why is it so difficult to find suitable alternatives?，这一点在safew官方版本下载中也有详细论述
Apple’s new Containerization framework (announced at WWDC 2025) is interesting here. Unlike Docker on Mac, which runs all containers inside a single shared Linux VM, Apple gives each container its own lightweight VM via the Virtualization framework on Apple Silicon. Each container gets its own kernel, its own ext4 filesystem, and its own IP address. It is essentially the microVM model applied to local development, with OCI image compatibility. It is still early, but it collapses the gap between “local development containers” and “properly isolated sandboxes” in a way that Docker Desktop never did.
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